Prophylaxis of cytomegalovirus infection with ganciclovir in renal transplant recipients: a prospective randomized controlled study
- VernacularTitle:更昔洛韦预防肾移植术后巨细胞病毒感染的前瞻性随机对照研究
- Author:
Ming ZHANG
;
Jianyong ZHONG
;
Lianxi QU
- Publication Type:Journal Article
- Keywords:
Ganciclovir;
Cytomegalovirus;
Renal transplantation;
Prospective studies
- From:
Chinese Journal of Organ Transplantation
2005;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prophylactic treatment of cytomegalovirus (CMV) infection in renal transplant patients.Methods Fifty-five patients were divided into two groups. Group A (n=27) was administered with ganciclovir (5 mg/kg every day) intravenously for 30 days. Group B(n=28) was the control group. According to donor (D) or recipient (R) CMV antibody categories,each group had D+/R-,D-/R+,D+/R+ three subgroups. All patients were followed up prospectively for 6 months with measurements of CMV antibody,CMV-DNA antigen,acute rejection for monitoring activity of CMV infections.Results The rate of CMV infection and disease was similar in both groups. The delay between transplantation and CMV infection was significantly longer in the ganciclovir group than in the control group (70.1?14.9 vs 50.2?9.8,P
