Morphological changes of spinal motorneurons by early treatment after explosive injury of spinal cord
- VernacularTitle:脊髓爆震伤后早期治疗神经元的形态学变化
- Author:
Jie YU
;
Zhuojing LUO
;
Xuefei ZHANG
- Publication Type:Journal Article
- Keywords:
explosive injury of spinal cord;
medicine;
motorneuron;
morphology
- From:
Orthopedic Journal of China
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study therapeutic effect of different medicines on motorneuron of spinal cord after explosive injury of spinal cord.[Method]Thirty-six rabbits were randomly divided into model group(group A,n= 12),the dexamethasone experiment group(group B,n= 12) and the methylprednisolone experiment group(group C,n=12),all rabbits were made explosive wound by 0.9 g cyclotrimethylene trinitramine,group A injection NS after blast, group B injection dexamethasone and group C injection methylprednisolone,6 and 24 hours after specimen had been taken out,then morphological change and quantity of the spinal motorneurons be observed under light microscopes.[Result]The reversible change of the neurons of rabbits happened after six hours,after 24 hours,the died motoneuron increase obviously, some rabbits remedied with dexamethasone and methylprednisolone after explosive injury in group B and C,quantity of the died motorneuron marked significant difference than that in the control group(P0.05).[Conclusion]Glycocotical stdroid can protect spinal cord motoneurons after explosive injury of spinal cord.In the experiment,there is no preponderance in early treatment of explosive injury of spinal cord between methylprednisolone and dexamethasone.
