Two different types of malignant fibrous histiocytomas from pet dogs.
10.4142/jvs.2009.10.2.169
- Author:
Sun Hee DO
1
;
Il Hwa HONG
;
Jin Kyu PARK
;
Ae Ri JI
;
Tae Hwan KIM
;
Dong Mi KWAK
;
Kyu Shik JEONG
Author Information
1. Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
dog;
inflammatory;
malignant fibrous histiocytoma;
osteoclast-like giant cell
- MeSH:
Animals;
Biopsy/veterinary;
Dog Diseases/diagnosis/*pathology;
Dogs;
Female;
Histiocytoma, Malignant Fibrous/diagnosis/pathology/*veterinary;
Immunohistochemistry/veterinary;
Male;
Soft Tissue Neoplasms/diagnosis/pathology/*veterinary
- From:Journal of Veterinary Science
2009;10(2):169-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclast-like giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The latter case, the inflammatory cell type, exhibited a storiform-pleomorphic variant of neoplastic cells, including an ossifying matrix. MFHs are among the most highly aggressive tumors occurring in soft tissue sarcomas in elderly dogs; however, MFHs have been poorly studied from a diagnostic point of view. Herein, we describe the histologic and immunohistologic features of MFHs in detail, thus classifying the subtypes of these tumors.
