Effect of Gusuibu Zonghuangtong on level of TNF-? and IL-6 in macrophagocyte
- VernacularTitle:骨碎补总黄酮对巨噬细胞分泌细胞因子TNF-?、IL-6水平的影响
- Author:
Chunshui CAI
;
Ping XIAO
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
Gusuibu Zonghuangtong;
osteoporosis;
cytokine;
prosthesis
- From:
Orthopedic Journal of China
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study the effects of Gusuibu Zonghuangtong on level of TNF-? and IL-6 in macrophagocyte stimulated by PMMA particles.[Method]The rabbits were divided into six groups.Group A:only monoculear cells;group B:monoculear cells+PMMA particles;group C:monoculear eells+PMMA particles +2mlcontrol-serum;group D:monoculear cells +PMMA particles +2 ml drug-serum;group E:monoculear cells + PMMA particles +3 ml drug-serum;Group F:monoculear cells + PMMA particles +5 ml drug-serum.Each group was cultured for 4 hours,and then the TNF-? and IL-6 of each groupwas determined.[Result]The levels of TNF-? and IL-6 were much higher in Group B than that of Group A,much lower in Group D,E,F than that of Group C(P0.05).[Conclusion]The PMMA particles could stimulate macrophagocyte to excrete TNF-? and IL-6,which can be inhibited by Gusulbu Zonghuangtong.Gusuibu Zonghuangtong is hoped to have clinical utility in the prevention and treatment of aseptic loosening of prosthesis.
