ACUTE TOXIC RESPONSE OF METRONIDAZOLE DERIVATIVE IN MICE
- VernacularTitle:甲硝羟乙唑衍生物对小鼠的急性毒性反应
- Author:
Rujun YANG
- Publication Type:Journal Article
- Keywords:
metronidazole derivative;
acute toxic effect;
mice
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Metronidazole derivative (CM) administered intraperitoneally or intravenously could cause a marked dose dependent neurotoxic response.The mean LD50 was 5034 mg/kg in the three batches of CM intraperitoneally administered and their effect was statistically identical, and the mean LD50 was 3186 mg/kg in the three baches of CM intravenously administered and their effect was same although there was a significant difference between 8638 and 8646 batches which was probably due to the individual difference in Sensitivity to intravenous injection.
