The study on the expression of HIF-1? and its association with the expression of HER-2 and survivin in breast carcinoma
- VernacularTitle:HIF-1?在乳腺癌组织中的表达及与HER-2、Survivin表达的相互关系
- Author:
Xianglin YUAN
;
Shiying YU
;
Shu XIA
- Publication Type:Journal Article
- Keywords:
HIF-1?;
breast carcinoma;
HER-2;
survivinlan-mnerdehe
- From:
China Oncology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:HIF-1?、HER-2 and survivin are all considered as important prognostic factors of breast cancer,but the relationships among them are poorly understood.We investigated the expression of HIF-1?、HER-2 and survivin in Breast Carcinoma,and explored the relationship among the three prognostic factors.Methods:The expressions of HIF-1?、HER-2 and survivin were detected by immunohistochemistry in 51 human Breast Carcinoma samples.Results:① 28(54.88%),11(21.69%) and 35(68.62%) were positive for HIF-1?、HER-2 and survivin,respectively.② A significant difference was found in terms of the overexpression of HER-2 between the samples with HIF-1? either positive or negatiwe(P0.05).Conclusions:The positive expression of HIF-1? was strongly correlated with the overexpression of HER-2,but not survivin in breast carcinoma.
