The expressions of COX-2 and VEGF-C in stage Ⅱ and Ⅲ rectal cancer and its association with angiogenesis and prognoses
- VernacularTitle:Ⅱ、Ⅲ期直肠癌组织中COX-2和VEGF-C的表达及其与肿瘤血管生成及预后的关系
- Author:
Minghe WANG
;
Yingqiang SHI
;
Hongfen LU
- Publication Type:Journal Article
- Keywords:
rectal neoplasm;
cyclooxygenase;
vascular endothelial growth factor;
angiogenesis;
immunohistochemical staining
- From:China Oncology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Blood vessel metastasis often occurs after the operation of rectal cancer of stage Ⅱ and Ⅲ,angiogenesis is an important step of the procedure.Cycloxygenase-2(COX-2) and vascular endothelial growth factor(VEGF-C) are correlated to angiogenesis. The purpose of this study is to investigate the expressions of Cycloxygenase 2(COX-2) and vascular endothelial growth factor(VEGF-C) in rectal cancer of stage Ⅱ and Ⅲ,to explore the relationships between them and the tumor biological characteristics,tumor angiogenesis.Methods:The expressions of COX-2,VEGF-C and the microvessel density(MVD) were detected by immunohistochemical staining.Results:①The positive rates of COX-2 and VEGF-C expression in rectal cancer were 72.5%,higher than those in peritumoral normal tissue(P
