Expression of cyclooxygenase-2 and its clinicopathologic and prognostic significance in endometrial cancer
- VernacularTitle:环氧合酶-2在子宫内膜癌中表达及临床意义的研究进展
- Author:
Zhi SUN
;
Huaying WANG
- Publication Type:Journal Article
- Keywords:
cyclooxygenase-2;
endometrial cancer;
clinical pathology;
prognosis
- From:
China Oncology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Cyclooxygenase-2(COX-2)is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers.Data indicate that COX-2 is involved in the regulation of apoptosis,angiogenesis,and immune response.The biological function of COX-2 appears to be associated with tumorigenesis.Recently, multiple studies have shown that COX-2 plays a critical role not only in maintenance of the endometrium during the menstrual cycle,but also in the progression of endometrial cancer.This review outlines the status of COX-2 expression and its association with clinicopathologic features and clinical outcome in endometrial cancer.
