Study of using ?-cyanoacrylate to establish the orthotopic transplantation tumor model from the subcutaneous model of human hepatocellular carcinoma in nude mice
- VernacularTitle:利用?-氰基丙烯酸烷基酯医用胶建立人肝癌裸鼠皮下-肝原位移植瘤模型的实验研究
- Author:
Junwen BAI
;
Chengwang YANG
;
Bingzhong SU
;
Xiulan SU
- Publication Type:Journal Article
- Keywords:
?-cyanoacrylate;
Tumor model;
Hepatocellular carcinomas;
Nude mice
- From:
Cancer Research and Clinic
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using ?-cyanoacrylate to establish the orthotopic transplantation tumor model from the subcutaneous model of human hepatocellular carcinomas(HCC)in nude mice. Methods The subcutaneous animal tumor model was established by transplanting BEL-7402 cell into the subcutaneous of nude mice. Then the orthotopic transplantation tumor model was established by injecting the subcutaneous transplanted tumor into liver(indirect orthotopic model). Results Using ?-cyanoacrylate to establish the indirect orthotopic model successfully and the survival rates of the transplantation tumor were 95.8 %. Conclusion It was compared with the traditional methods that the indirect orthotopic transplantation tumor model by using ?-cyanoacrylate to establish is an easy method with high successful rate and easy to spread.
