The immuohistochemical investigation of mucose amelanotic malignant melanoma
- VernacularTitle:黏膜无色素性恶性黑色素瘤的免疫组化及临床研究
- Author:
Lixia WANG
;
Zhetao MI
;
Weidong YIN
;
Quanhong WANG
;
Jinfen WANG
- Publication Type:Journal Article
- Keywords:
Immuohistochemical investigation;
Mucose amelanotic malignant melanoma;
Lymphanoid metastasis
- From:
Cancer Research and Clinic
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expression of CD56, CD95(Fas), Ki-67, p53, bcl-2, HMB45 and S-100 in mucosa amelanotic malignant melanoma in order to improve the pathological diagnosis level reduce wrong diagnosis and avoid missing dignosis, and afford objective factors for prognosis and therapy. Methods The techniques of tissues chips and immunohistochemical lablling were used for analyzing 48 cases of mucosa amelanotic malignant melanoma. Results The positive rates of HMB45 and S-100 were 100 % (48/48) and 85.4 % (41/48) respectively. The positive rate of CD56 was 91.6 % (44/48), there was not statistical difference between original cases and metastatic cases. The positive rate of CD95 was 85.4 %(41/48). In which it is 100 % (11) in 11 cases of having lymphanoid metastasis. The positive rates of Ki-67 and p53 were 79.2 % (38/48) and 58.3 % (28/48) respectively. The positive distribution of Ki-67 was almost same as CD95. The positive rate of bcl-2 was 39.6 % (19/48), the positive expression was significantly different between p53 and bcl-2(P
