The observation of clinical efficacy of rituximab in combination with DHAP chemotherapy in patients with relapsed non-hodgkin lymphoma
- VernacularTitle:利妥昔单抗联合DHAP方案治疗复发性非霍奇金淋巴瘤的临床疗效
- Author:
Jiyu WEN
;
Zhong XIE
;
Jierong XIE
- Publication Type:Journal Article
- Keywords:
Rituximab;
DHAP chemotherapy;
non-Hodgkin's lymphoma
- From:
Cancer Research and Clinic
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the safety and efficacy of the combination of rituximab and DHAP chemotherapy in patients with relapsed non-Hodgkin lymphoma(NHL). Methods To choose 16 patients with relapsed B-cell NHL as research objects, they were divided into two groups: treatment and control group. The treatment group(8 cases) received the combination of rituximab and DHAP chemotherapy; the control group (8 cases) received combination chemotherapy. The treatment was first infused a dose of rituximab (375 mg/m2) the day before receiving the DHAP chemotherapy, and such treatment being repeated for 4 ~ 6 times every other week. The DHAP chemotherapy lasts 4 ~ 6 cycles and twenty-one days in each cycle. The control group was primitively administrated 4 ~ 6 cycles of CHOP chemotherapy, methotrexate, Ara-C and etoposide as additional drug. Results The complete response and overall response rate were 75 % and 100 % while in the control group were 37.5 % and 62.5 %. The progression-free and overall survival was (18.3?5.4) months significantly higher than that of the control group [(4.7?2.8) months, P
