The role mechanism of alpha fetoprotein in escaping immune surveillance of hepatoma cells
- VernacularTitle:甲胎蛋白在肝癌细胞免疫逃避中的作用机制
- Author:
Mengsen LI
;
Gang LI
- Publication Type:Journal Article
- Keywords:
Alpha fetoprotein;
Immune surveillance;
Hepatoma cells
- From:
Cancer Research and Clinic
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Alpha fetoprotein(AFP) plays multi-role in regulating the growth of hepatocellular carcinoma cells, because of AFP has a complex molecular structure. AFP not only can promote the proliferation of hepatoma cells, but also can inhibit the immune response in liver cancer patients. Recently, documents showed that AFP has a capability to impair the function of dentritic cells(DCs), and AFP could induce DCs to death. AFP restrain DCs transform to matured antigen presenting cell through regulating the phenotype molecule express in the membrane of DCs, and AFP also influence the expression of tumor necrosis factor family and its receptor in lymphocytes or in hepatoma cells, AFP also could inhibit the activity of caspase in tumor cells, possesses these effects of AFP result in the hepatoma cells escape the immune surveillance.
