Effects of As_2O_3 on Expression of NF-?B p65,Survivin and Caspase-3 in Human Breast Cancer
- VernacularTitle:As_2O_3对人乳腺癌中NF-?B p65、survivin和caspase-3的作用及相关性研究
- Author:
Yinbin MA
;
Chengyi WU
;
Xin CHEN
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide Breast neoplasm Gene
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of As_2O_3 on expression of NF-?B p65, survivin and caspase-3 in human breast infiltrating duct carcinoma xenograft model on nude mice. Methods A human breast infiltrating duct carcinoma model on nude mice was established and the nude mice were divided randomly into three groups: control group, DDP group and As_2O_3 group (1.5 and 3.0 mg/kg concentrations). The expression of survivin mRNA was detected with the method of in situ hybridization and the expressions of NF-?B p65, survivin and caspase-3 protein were measured with immunohistochemistry. Results The positive rates of NF-?B p65 and survivin expression were higher in the control group than those in the DDP group and the As_2O_3 groups, but that of caspase-3 was on the opposite way (P
