Correlation Between Homocysteine and Anti-Phospholipid Antibodies and the Formation and Recurrence of Thrombus in Deep Vein
- VernacularTitle:同型半胱氨酸及抗磷脂抗体与深静脉血栓形成和复发关系的研究
- Author:
Yingnan ZHANG
;
Qingfeng SUN
;
Haitao WANG
;
Weiliang JIANG
- Publication Type:Journal Article
- Keywords:
Deep venous thrombosis Homocysteine Anti-phospholipid antibody
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the levels of homocysteine (Hcy) and anti-phospholipid antibodies (APLA) in the hematoplasma of the patients with deep venous thrombosis (DVT), discuss the reason of DVT recurrence and search for the predictors of it. Methods Sixty cases with DVT in our department from January 2001 to April 2003 were collected, which were divided equally into two groups as primary and recurrent, and first degree relative of the 30 DVT recurrent patients were also collected. The author established a control group using 30 cases of out-patient clinic without varicose veins of lower extremity or insufficient venae profundae. Hcy was detected with fluorescence polarization immunoassay (FPIA) and APLA 〔anticardiolipin antibody, ACLA (IgG, IgM); lupus antibody (LA)〕were detected with enzyme linked immunosorbent assay (ELISA). Odds ratios (OR) were also calculated to assess the relative risk of each study group. Results The values of Hcy and ACLA (IgG, IgM) in the primary group and recurrent group were both significantly higher than those of control group and first degree relative group of DVT recurrent patients (P
