Role of PPAR? in Pathogenesis of Colorectal Cancer
- VernacularTitle:结直肠癌发病机理的新位点——PPAR?
- Author:
Lie YANG
;
Zongguang ZHONG
- Publication Type:Journal Article
- Keywords:
Colorectal cancer Peroxisome pro1iferator-activated receptor Pathogenesis
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of PPAR? in the pathogenesis of colorectal cancer. Methods Literatures about PPAR? and the pathogenesis of colorectal cancer were reviewed and analyzed.Results PPAR? is expressed in the nucleuses of glandular epithelia lining colon and rectum. It is normally suppressed by wild-type adenomatous polyposis coli (APC) but is up-regulated by enhanced ?-catenin/T cell factor-4 (TCF-4) binding to TCF-4-responsive elements in the PPAR promoter when an inactivating APC mutation occurs, which indicates PPAR is a potential downstream target of the APC/?-catenin/TCF-4 signaling pathway in colorectal cancer. Consistent with PPAR’s role as an APC/?-catenin/TCF-4 target, some studies reported that PPAR mRNA is frequently overexpressed in colorectal cancers of both humans and rodent animals, which indicates that PPAR is relevant to the tumorigenesis of colorectal cancer. Conclusion PPAR? is closely related with the pathogenesis of colorectal cancer.
