DNA Damage Induced by Chlorinated Acetic Acids, the Drinking Water Disinfection By-products
- VernacularTitle:饮水氯化消毒副产物的氯乙酸类化合物的DNA损伤效应
- Author:
Yuan YANG
;
Zhengchang HENG
- Publication Type:Journal Article
- Keywords:
Water;
Disinfection;
DNA damage;
Disinfection by-products;
Dichloroacetic acid;
Trichloroacetic acid;
Comet assay
- From:
Journal of Environment and Health
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the DNA damage induced by dichloroacetic acid(DCA) and trichloroacetic acid(TCA) which are from drinking water disinfection by-products. Methods V79 cells and hepatocytes of mice were treated with DCA and TCA for 1 hour and then were tested by comet assay. After stained by EB, tail length of the cells were observed and counted under the fluorescence microscope. Results Both DCA and TCA could result in the increasing of average tail length of the treated cells whether they were V79 cells or hepatocytes of mice and the dose-response relationships were seen. Conclusion Both DCA and TCA can cause DNA damage of mammalian cells and this may be related to the carcinogenic mechanism. DCA and TCA belong to genetic carcinogens.
