Application of IL-15mRNA determination in the early diagnosis and differential diagnosis of early acute rejection following liver transplantation
- VernacularTitle:IL-15mRNA测定在肝移植后早期急性排斥反应诊断与鉴别诊断中的应用
- Author:
Yahong YU
;
Qifa YE
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Graft rejection;
Bacterial infections;
Bile;
Interleukin-15
- From:
Chinese Journal of Organ Transplantation
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of IL15mRNA determination in the early diagnosis and differential diagnosis of acute rejection(AR) after liver transplantation.Methods RT-PCR was used to detect the mRNA of IL-15 in serum and bile on the 30th day after liver transplantation in 43 patients subject to orthotopic piggy-back liver transplantation.Serum and bile of the patients were cultured for bacteria.The acute rejection was confirmed pathologically. Results Acute rejection(occurred) in 16 out of 43 cases as the AR group and bacterial infection(BI) in 12 cases as the BI group.The (remaining) 15 patients were uneventful as the control group.Before diagnosis of AR and BI,the gene expression rate of IL-5 in bile was significantly higher in AR group((62.5 %)) than in BI group((16.7 %)) and control group((13.3 %))(P
