Expression of HBsAg,Fas and PCNA in hepatocellular carcinoma and their significance in understanding HBV related hepatocarcinogenesis
- VernacularTitle:原发性肝细胞癌HBsAg、Fas和PCNA抗原的表达及其意义
- Author:
Runde JIANG
;
Ning ZONG
;
Zhanyuan LI
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular?Hepatitis B surface antigens?Antigens,CD95?Proliferating cell nuclear antigen
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressive characters and their significance by detecting the expressions of HBsAg,Fas and proliferating cell nuclear antigen(PCNA) in both hepatocellular carcinoma(HCC) and their surrounding non-cancerous tissues.The correlation between HBV infection and HCC,and the possible mechanism of hepatocellular carcinogenesis were discussed.Methods:HBsAg,Fas and PCNA were detected by immunohistochemistry from 52 cases of hepatocellular carcinoma as well as 42 corresponding non-cancerous tissues.Clinical data suchas serum AFP levels was also analysed.Results:Both HBsAg and Fas were strongly expressed in non-cancerous tissues,with positive rate of each achieving 78.6%.However their expression rates in cancer tissues were 21.2% and 30.8% respectively,significantly lower and less intensive than that of their corresponding non-cancerous ones(P
