Cationic liposomes complexed to plasmids encoding endostatin and angiostatin inhibit lewis lung cancer in mice model
- VernacularTitle:SA脂质体介导血管抑素和/或内皮抑素基因治疗Lewis肺癌小鼠的实验研究
- Author:
Zhenbin LI
;
Xiefei QI
;
Weihua RAO
- Publication Type:Journal Article
- Keywords:
Cationic liposomes complexed to plasmids encoding endostatin;
Angiostatin;
Lewis lung cancer;
Mice model
- From:
Cancer Research and Clinic
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the inhibitory effect of cationic Liposomes complexed to plasmids encoding endostatin and/or angiostatin on the growth and metastasis of Lewis lung cancer in mice model. Methods C57BL/6j mice were established as mice model. Cationic liposome complexed plasmids encoding angiostatin and endostatin were administrated intratumorally to inhibit the growth and metastasis of the implanted tumor. The size change of the tumor; metastasis in lung, the activity, nourishment, survival period of the mice were observed to evaluate the function of cationic liposome complexed plasmids. Results The treatment group could inhibit the growth and metastasis of the implanted tumor. Comparing with control group, they showed significance in tumor size, metastasis in lung and survival period of the mice (P
