Expression of inhibitors of apoptosis (IAPs) and its clinical significance in patients with non-small cell lung cancer
- VernacularTitle:凋亡抑制因子在非小细胞肺癌中的表达及其意义
- Author:
Xuyu LANG
;
Zhen FENG
;
Jianbin ZHAO
;
Jun XIE
- Publication Type:Journal Article
- Keywords:
Expression of inhibitors of apoptosis;
Non-small cell lung cancer
- From:
Cancer Research and Clinic
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of inhibitors of apoptosis (IAPs) in non-small cell lung cancer (NSCLC) patients and its clinical significance. Methods The mRNA expression level and protein level of survivin, hIAP-1 (human IAP-1), hIAP-2 (human IAP-2), and XIAP (X chromosome-linked IAP) in 36 NSCLC patients and 36 controls were analyzed by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blotting, respectively. Results High survivin mRNA expression were detected in 32 out of 36 patients, but not in controls. 26/36 NSCLC showed high XIAP mRNA expression and were significantly higher than those with benign diseases (P
