The development of predicting the lung cancer resistance to gemcitabine by the expression levels of RRM1
- VernacularTitle:RRM1基因表达水平预测肺癌对吉西他滨耐药性的研究进展
- Author:
Song DONG
;
Yilong WU
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Drug resistance;
Gemcitabine;
Expression of RRM1
- From:
Cancer Research and Clinic
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Gemcitabine is important pyrimidine antimetabolites drug. Ribonucleotide reductase is oneof its targets whose overexpression has been observed in several gemcitabine- resistant cell lines. Meanwhile,the NSCLC patients with high RRM1 expression levels have a relatively poor survival when treated with gem-citabine. To this day, the relationship between RRM1 expression levels in peripheral blood mononuclear cellsand gemcitabine is still uncertain and it deserves further research.
