The Affect of Chronic Stress to Ultrastructure and Expression of Vascular Cell Adherence Molecules-1 in Thoracic Aorta in Rats
- VernacularTitle:慢性应激对大鼠主动脉超微结构和血管细胞粘附分子-1表达的影响
- Author:
Xumei WANG
;
Yanhui LI
;
Jing XIA
- Publication Type:Journal Article
- Keywords:
Chronic Stress;
Rat;
Aorta;
VCAM-1;
Mitochondria
- From:Chinese Journal of Clinical Psychology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Studying the affect of chronic stress to ultrastructure and the expression of vascular cell adherence molecules-1 in thoracic aorta in rats. Methods: 24 male Wistar rats are divided into two groups randomly, including the test group and control group. The number of each group is 12. The test group are compelled to receive a series of stimulation after they are fed 1 week in quiet surrounding, but the control group are not. All of rats are executed at the same time. After have drawn the materials from the thoracic aorta, we observe the ultrastructure by electronic microscope and the expression of vascular cell adherence molecules-1 by the method immunohistochemistry in thoracic aorta. Results: ①The ultrastructures in test group are changed, but the control group are normal; the modification is concentrated on the obvious swelling, vacuolicitical transformation in mitochondria, but the control are not. ②The VCAM-1 is highly expressed in thoracic aorta of the test group, there is not in control group(P
