Effect of anti-CD25 monoclonal antibody for prophylaxis and therapy of acute GVHD and immune reconstitution following HLA haplotype related T-cell undepleted allogeneic bone marrow transplantation
- VernacularTitle:巴利昔单抗在骨髓移植中防治急性移植物抗宿主病和免疫功能重建中的作用
- Author:
Hongmin YAN
;
Shuquan JI
;
Hengxiang WANG
- Publication Type:Journal Article
- Keywords:
Antibodys,monoclonal;
Bone marrow transplantation;
Graft vs host disease
- From:
Chinese Journal of Organ Transplantation
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
(0.05)).It was noted that the number of CD4~(+) T cells was less significantly throughout the 18 months after BMT in two groups.The time to reach 200 CD4~(+)cells/ ?l was 6 months,and that to reach normal number of CD4~(+)was 18 months.Median time to reach normal CD3~(+) CD8~(+) and CD19~(+) was 9-12 months,and there was no significant difference between two groups.Conclusions The incidence of severe lethal aGVHD and GVHD-related deaths tended to be less in patients with Basiliximab group than un-treated group in haploidentical BMT.It is useful to use Basiliximab to treat sever GVHD.CD4~(+) reconstitution appeared significantly delayed in two groups.CD4~(+) reconstitution is crucial to control post-transplant opportunistic infections and leukemia relapse.Nevertheless,there was no significant difference in immune reconstitution and the incidence of infection and relapse between the two groups.
