Successful treatment of severe hemorrhagic cystitis following allogeneic stem cell transplantation by selective embolization of bilateral internal iliac arteries
- VernacularTitle:选择性双侧髂内动脉栓塞治疗异基因造血干细胞移植术后重度出血性膀胱炎
- Author:
Xiaowen TANG
;
Yizhi LIU
;
Xiaoli ZHU
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Cystitis,severe;
Radiology,interventional
- From:
Chinese Journal of Organ Transplantation
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic value of embolization in severe hemorrhagic cystitis(HC) following allogeneic stem cell transplantation.Methods Six patients undergoing allogeneic stem cell transplantation developed severe HC with a median onset time of 33 days after transplantation.All these patients had been resistant to conservative managements and received the treatment of selective embolization of bilateral internal iliac arteries.Results Eight times of embolizations were performed for 6 patients.The HC was cured in 4 patients and the HC improved in 1 patient,yielding a response rate of 83 %.One patient didn't respond to this measure.For the patients with response,macroscopic hematuria disappeared 7 to 10 days after the treatments and microscopic hematuria vanished 20 to 30 days after the intervention therapy.Both procedures were tolerated well and no severe adverse effects were observed.Conclusions Selective embolization of internal iliac arteries seems to be a safe and effective treatment for severe HC.This measure can be proposed for patients undergoing refractory and persistent severe HC.
