Experimental Investigation of Correlation Between MSCT Perfusion and Blood Lipid in Steroid-induced Avascular Necrosis of Femoral Head
- VernacularTitle:激素性股骨头缺血坏死的血脂与MSCT灌注成像相关性的实验研究
- Author:
Yue DONG
;
Feng WEN
;
Zhenhua WU
;
Guoguang FAN
- Publication Type:Journal Article
- Keywords:
femoral head necrosis;
hormone;
blood lipid;
tomography,X-ray computed;
perfusion
- From:
Journal of Practical Radiology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between change of blood lipid and MSCT perfusion imaging in steroid-induced femoral head necrosis in adult rabbits.Methods 20 rabbits 1~1.5 years old in age were divided into two group:16 rabbits in experimental group,8 mg/kg Methylprednisolone was injected twice a week;4 rabbits were used as control group.At 2,4,6,8 week after injection,4 rabbits in experimental group and 1 rabbit in contral group were killed respectively.Before killing the rabbits,the blood lipid was examined and MSCT perfusion imaging was done and the correlation between them was analysed.The index of TRIG,CHOL,Perfusion,PEI,TTP,MTT.All femoral heads were undergone pathological investigation.Results Two weeks after injection,blood lipid began increasing,then blood flow of femoral head decreasing obviously with prolongation of injection;PEI and MTT decrease only 4 weeks after injection.There were a negaitive correlation between blood lipid and blood flow of femoral head.Conclusion There were obviously correlation between the level of increasing blood lipid and blood flow decreasing in steroid-induced avascular necrosis of femoral head in rabbit.
