Change of TNF-?and VEGF on glucocorticoid-induced avascular necrosis of femoral head in rabbits
- VernacularTitle:TNF?和VEGF在激素性股骨头坏死中的变化
- Author:
Zhiming HU
;
Haibin WANG
;
Zuguo LI
- Publication Type:Journal Article
- Keywords:
Osteonecrosis of femoral head;
Tumor necrosis factor-?( TNF-?);
Vascular endothelial growth factor(VEGF)
- From:
Orthopedic Journal of China
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To establish animal model of avascular necrosis of the femoral head in rabbits induced by glucocorti-coid, to further investigate the pathogenesis of glucocorticoid-induced osteonecrosis.[Method]Twenty NewZealand white rabbitswere used and randomly divided into two groups.Group A was injected with horse serum and prednisone. Group B was used asthe control.The concentration of TNF-?was measured by ELISA in rabbits serum of group A and group B.Femoral head speci-mens were studied by histopathologic examination and the expression of VEGF by immunohistochemical examination.[Result]The concentration of TNF-?in rabbits serum of group A was higher than that of group B(P
