Relationship of angiotensin-converting enzyme, angiotensinogen and endothelial nitric oxide synthase gene polymorphisms with coronary disease in aged people
- VernacularTitle:基因芯片技术分析老年冠心病患者的易感基因
- Author:
Xi LIANG
;
Yugang DONG
;
Xili YANG
;
Guang YANG
;
Jinhuan CUI
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Gene expression;
Angiotensinogen;
Nitric-oxide synthase
- From:
Chinese Journal of Geriatrics
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predisposition effects of angiotensin-converting enzyme (ACE) ,angiotensinogen (AGT) and endothelial nitric oxide synthase (eNOS) gene polymorphisms on coronary disease (CHD) as well as their possible synergistic effect in the development of CHD in Chinese aged people. Methods The study included 191 subjects (100 CHD and 91 controls). Gene chip technology was performed. The allele frequency and genotype distribution were compared between groups. Results A significantly higher frequency of the DD genotype of ACE gene was observed in CHD group (28.0% vs 15. 4%, P0. 05). Subjects carrying ACE DD and AGT TT genotypes or those carrying AGT TT and eNOS TT genotypes showed a stronger association withCHD(OR=2. 9, P
