Expression of human telomerase reverse transcriptase in oral submucous fibrosis and carcinogenesis of oral submucous fibrosis
- VernacularTitle:口腔黏膜下纤维性变及其癌变组织中端粒酶逆转录酶表达
- Author:
Yijun GAO
;
Tianyou LING
;
Xiaomin YIN
- Publication Type:Journal Article
- Keywords:
Oral submucous fibrosis;
Carcinogenesis;
Human telomerase reverse trascriptase;
Immunohistochemistry
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of human telomerase reverse transcriptase(hTERT) in carcinogenesis of oral submucous fibrosis(OSF).Methods:The expression of hTERT was examined by immunohistochemical SP method in 10 cases of normal oral mucosa, 46 cases of OSF,14 of carcinogenesis of OSF and 10 of adjacent non-cancerous OSF tissue. Results:The expression of hTERT was negative in normal oral muscosal epithelium.The frequency of hTERT positive expression was higher in carcinogenesis lesions of OSF(12/14) than those in OSF(7/46)(P
