Slit expression and its correlation with microvascular dense of hamster buccal-pouch carcinogenesis
- VernacularTitle:Slit蛋白在地鼠颊囊癌变过程中的意义及与血管形成的关系
- Author:
Yuan ZHAO
;
Lijing WANG
;
Bing HAN
- Publication Type:Journal Article
- Keywords:
Slit;
Hamster buccal pouch;
Hamster;
Angiogenesis
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe slit expression on the model of DMBA induced cheek pouch caricnoma in hamsters in various stages, so as to elucidate the relationship between slit expression and angiogenesis.Methods:Carcinogenesis model (HBPCa) was established in 60 hamsters by topical application of 5 g/L DMBA in left buccal pouch three times per week for 14 weeks.Slit expression, vascular endothelial growth factor (VEGF) and von Willebrand factor (v-WF) were examined by immunohistochemical staining,microvascular dense(MVD) was measured 6-16 weeks respectively after application of DMBA.Results:Carcinoma was developed in all the hamsters.Slit,VEGF and v-WF expression and MVD were all increased with the development of carcinoma(P
