Expression of estrogen receptor in human tongue cancer cells
- VernacularTitle:雌激素受体在人舌癌细胞系中的表达
- Author:
Hongyu WEI
;
Junzheng WU
;
Hongjie ZHANG
- Publication Type:Journal Article
- Keywords:
Estregon receptor;
Human tongue cancer cell line;
Internal hormone therapy;
Metastsis
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression of estrogen receptor alpha(ER?) and beta(ER?) in human tongue cancer cell line Tca8113 and its highly metastatic cell line Tb. Metheds:Immunocytochemistry, RT-PCR methods were used to observe the expression of ERs in the in vitro cultured human tongue cancer Tca8113 and Tb cells.Results:ER? and ER? mRNA were expressed in both cell lines,and the expression of ER? in Tb cells was stronger than that in Tca8113 cells, the expression of ER? was the same in the two cell lines. The ratio of ER? to ER? was higher in Tb cells than that in Tca8113 cells.Conclusion:The overexpression of ER? and ER?/ER? ratio may be associated with the higher potential of metastasis of Tb cells.
