Expression of u-PA and PAI-1 in oral submucous fibrosis
- VernacularTitle:口腔黏膜下纤维性变中u-PA和PAI-1的表达及意义
- Author:
Changyun FANG
;
Yu XIA
;
Xuemei ZHANG
- Publication Type:Journal Article
- Keywords:
Oral submucous fibrosis;
Uroinase type plasminogen activator;
Type I plasminogen activator inhibitor
- From:
Journal of Practical Stomatology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of u-PA and PAI-1 and their possible role in oral submucous fibrosis(OSF). Methods:Immunohistochemistry and imaging analysis were used to detect the expression of u-PA and PAI-1 in 30 cases of OSF and 10 cases of normal control.Results:The expression of u-PA and PAI-1 was observed in the cytoplasm of blood vessel endothelium,fibroblasts and inflammatory infiltration cells in lamina propria of OSF and control samples.u-PA expression was increased at the early stage of OSF(P0.05).PAI-1 expression was increased following the development of the disease(P
