Expressions of CyclinD1 and nm23H1 related to the response of neoadjuvant chemotherapy and prognosis in cervical carcinoma
- VernacularTitle:宫颈癌新辅助化疗的临床价值及化疗后CyclinD_1和nm23H_1的表达
- Author:
Shuli SHAO
;
Ruixia ZHAO
;
Lixia WANG
;
Quanhong WANG
;
Xuye ZHAO
- Publication Type:Journal Article
- Keywords:
CyclinD1;
nm23H1;
Neoadjuvant chemotherapy;
Prognosis;
Cervical carcinoma
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the expressions CyclinD1 and nm23H1 and the response to neoadjuvant chemotherapy (NACT) in cervical carcinoma. Methods 100 patients with cervical cancer were enrolled in this study. These patient were randomly divided into two groups. The observed group were treated by neoadjuvant chemotherapy followed by radical hyterectomy and lymphonectomy. The other 50 cases were treated by operation as control group. The expression of CyclinD1 and nm23H1 were examined by immunohistochemistry using post-operation specimens. Results The total response rate of neoadjuvant chemotherapy was 75 %( CR+PR). The expression rate of CyclinD1 was 76 % in experimental group, and 54 % in control group(P 0.05). Conclusion The neoadjuvant chemotherapy was helpful for the patients with local advanced stage of cervical carcinoma. CyclinD1 may be one of the path of NACT, but nm23H1 may not related to NACT.
