Expression and significance of matrix metalloproteinase 2 and its tissue inhibitor in human endometrial carcinoma
- VernacularTitle:基质金属蛋白酶2及其组织抑制因子2在子宫内膜癌中的表达及意义
- Author:
Xiujie SHENG
;
Jin YAN
;
Hecun SONG
;
Yifeng WANG
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 2;
Tissue inhibitor;
Endometrial carcinoma
- From:
Cancer Research and Clinic
1999;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the express of matrix metalloproteinase(MMP)-2 and tissue inhibitor of metalloproteinase(TIMP)-2 protein in human endometrial carcinoma. Methods The Immunohistochemistry was used to measure the MMP-2, TIMP-2 in endometrial carcinoma tissue of 40 patients, the atypical hyperplasia of 12 samples and the normal endometrium of 12 samples. Results The positive express of MMP-2 and TIMP-2 in the normal endometrium , atypical hyperplasia and endometrial carcinoma was increased gradually. In endometrial carcinoma, with progression of clinical stage and decrease of histological grade as well as deepening of cancer invasion, the ratio of MMP-2/TIMP-2 was increased. Conclusions The expression of MMP-2 and TIMP-2 were connected with endometrial carcinoma. The imbalance of MMP-2/TIMP-2 in the endometrial cancer might be one of the pathogenesis and development.
