Experimental study on thrombus-targeted ultrasound contrast agent enhancing acute thrombus in normal canine femoral vein
- VernacularTitle:血栓靶向超声造影剂对犬股静脉急性栓塞后血栓增强效果研究
- Author:
Genshan HE
;
Hong AI
;
Bing WANG
;
Xiaoping REN
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Contrast media;
Femoral vein;
Venous thrombosis
- From:
Chinese Journal of Ultrasonography
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the enhancement effect of the thrombus-targeted ultrasound contrast agent on acute thrombus in normal canine femoral vein.Methods Acute thrombi were created in both sides of the femoral vein in ten canine models.Targeted ultrasound contrast agent was given in a dose of(0.06) ml/kg in ten canines via intravenous bolus injection from forelimb of canine,the images of the acute thrombus were taken at 0,2,4,8,12,14 minutes after infusion of ultrasound contrast agent and stored in magneto optical disks.The images were assessed qualitatively by two independent observers and quantitatively using acoustic densitometry(AD) to determine the contrast enhancement effect of acute thrombus in normal canine femoral vein.Results After infusion of targeted ultrasound contrast agent,the thrombus was enhanced considerably and easy to be detected.AD analysis demonstrated that peak indencity(PI) and area under curve(AUC) increased with the changes of time,reaching the peak at 8th minutes after infusion of targeted ultrasound contrast agent,then decreased.PI and AUC increased at the 8th minute after infusion of targeted ultrasound contrast agent than before [((333.21)?(38.56))dB vs((168.18)?(28.18))dB,((884.40)?(94.62))dB vs((439.65)?(98.54))dB,respectively,P
