Effect of Uroacitides on Cell Cycle Progression of Breast Cancer Cells
- VernacularTitle:尿多酸肽对乳腺癌细胞周期的影响
- Author:
Wei ZHENG
;
Lin MA
;
Lin CHEN
;
Rong LI
;
Yanyong JIANG
- Publication Type:Journal Article
- Keywords:
Breast cancer Uroacitide Retinoic acid Cell cycle[Foundation item]National Natural Foundation of China (No.30171066)
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of CDA-Ⅱ on the cell cycle progression of breast cancer cells.Methods The effects of CDA-Ⅱ on growth curve, cell cycle progression and morphology of breast cancer cell lines MCF-7 and MDA-MB-231 were observed when CDA-Ⅱ and MCF-7 or CDA-Ⅱ and MDA-MB-231 were blended to cultivate in vitro, in comparison with the classical cell differentiation inducer ATRA. Results CDA-Ⅱ decreased the growth speed and inhibit proliferation ability in breast cancer cell lines MCF-7 and MDA-MB-231.It caused G0/G1 phase block of cell cycle and reduced the rate of S phase of breast cancer cells. Conclusion CDA-Ⅱ has remarkable effect of anti-cell-proliferation and can induce cell cycle block of G0/G1 on breast cancer cells. This results provide experimental bases for the treatment of breast cancer with CDA-Ⅱ.
