Changes and Mechanism of Colon Motility of the Rats in Multiple Organ Dysfunction Syndrome Induced by Bacterial Peritonitis
- VernacularTitle:细菌性腹膜炎诱导大鼠多器官功能不全综合征后结肠运动的变化和机理
- Author:
Zheyu CHEN
;
Qinghui QI
;
Lnan YAN
- Publication Type:Journal Article
- Keywords:
Induce nitricoxide synthase Interleukin-6 Tumour necrosis factor-? Multiple organ dysfunction syndrome Colon motility
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of colon motility of the rats in multiple organ dysfunction syndrome (MODS) induced bacterial peritonitis and the effects of IL-6, TNF-? and induce nitricoxide synthase (iNOS) on colon motility. Methods Wistar rats were divided into two groups, which were the control group and the MODS group. The number of stool, the amplitude changes of circular smooth muscle strip, the length of smooth muscle cell, and the changes of serum NO in two groups were observed. The expressions of IL-6, TNF-? and iNOS protein and IL-6 mRNA, TNF-? mRNA and iNOS mRNA in distal colon were investigated by using immunohistochemical methods and RT-PCR. Results The numbers of stool and the amplitude in the MODS group were lower than those of the control group (P
