Effect of Different Iodine Intake on Antioxidative Capability and Related Gene Expression in Brain of Rat Offspring
- VernacularTitle:不同碘摄入水平对仔代大鼠脑组织抗氧化能力及相关基因表达的影响
- Author:
Laixiang LIN
;
Yina SUN
;
Zhenkun YE
- Publication Type:Journal Article
- Keywords:
Iodine;
Brain;
Lipid peroxidation;
Gene expression
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of iodine on antioxidative capability by observing activity of antioxidative enzymes and related gene expression, and peroxide content in the brain of rat offspring. Methods One-month weaning Wistar rats were divided into four groups(low iodine-LI, normal iodine-NI, ten-fold high iodine-10HI and fifty-fold high iodine-50HI), and fed with water containing different iodine concentration by adding potassium iodate respectively. Rats mate randomly after three months.The offspring were sacrificed at 28 days after birth, then the activity of SOD and GSH-Px, and MDA content in brain tissue were tested, and the SOD and GSH-Px mRNA expression were measured by RT-PCR. Results Compared with the NI group, only in LI group MDA content were increased significantly (P
