Effect of IMA,Organic Tin Heat Stabilizer,on the Level of Sex Hormones in Rats
- VernacularTitle:双巯基乙酸异辛酯二正辛基锡对大鼠生殖内分泌激素的影响
- Author:
Jun HU
;
Jie LI
;
Kuiwei ZHANG
- Publication Type:Journal Article
- Keywords:
Environmental pollutant;
Environmental endocrine disruptors;
Imarcaptoacetate dioctyltin;
Sex hormones;
Testosterone
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand whether Imarcaptoacetate dioctyltin(IMA) is a environmental endocrine disruptor or not. Methods The new born Wistar rats were randomly divided into six groups including positive control group, negative control group and four experimental groups. The rats in the experimental groups were given IMA at different concentrations (0.100 0, 0.010 0, 0.001 0, 0.000 1 ?g/10 g) 1/1 000 000 by hypodermic injection, the rats in the negative control group were treated with corn oil and those in the positive control group were treated with dibutyltin dilaurate(DBTD) at concentration of 0.001 ?g/10 g bw. The rats were injected one time each day for five consecutive days. After one and half months, the levels of T, LH and FSH in the blood, the weight of the testicles, ovaries and the sexual organ exponent were determined. The pathological examination on some samples was conducted. Results In both of female and male, the levels of T in IMA treated rats were significantly increased and showed an doge-effect relationship (P0.05). The exponents of the testicles were different among groups (P
