Effects of Lead Exposure on Study, Memory and Autonomic Activities of Mice
- VernacularTitle:铅对小鼠学习记忆及自主活动的影响
- Author:
Zhenhua REN
;
Guangwu LI
- Publication Type:Journal Article
- Keywords:
Lead poisoning, nervous system;
Maze learning;
Memory
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the neurotoxicity of lead to mice and the mechanism. Methods Two months old(grown) and two weeks old(infancy) mice were employed, 1 ?l of 1 mol/L lead acetate was given by brain ventricle injection, 3 d, 5 d, 1 week, 2 weeks and 3 weeks after treatment with lead, the change of autonomic activities and the ability of study and memory of the mice were examined. Results The latency period of Lashley Ⅲ water maze prolonged significantly in grown group and the infancy group compared with the control groups at every time point of test. Conclusion Lead exposure can damage the function of study and memory of mice, and increase the frequency of autonomic activities of theirs.
