The Research of Imaging Features and Expression of BMP-2 Protein in Osteosarcoma Involved Epiphyseal Plate
- VernacularTitle:骨肉瘤侵袭骺板的影像学与BMP-2表达的研究
- Author:
Weiwei ZHANG
;
Qianghua MA
;
Xiaoping YANG
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
epiphyseal plate;
BMP-2;
radiography;
MRI
- From:
Journal of Practical Radiology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between BMP-2 protein and possible mechanism and to compare the postive rate of two different imaging examinations in evaluating the epiphyseal plate involved by osteosarcoma.Methods Radiographic and MRI features of epiphyseal plate extension by osteosarcoma confirmed by pathology in 36 cases were analysed retrospectively.The expression of BMP-2 was detected with immunohistochemical SABC method in different part of specimen.Results The diagnostic accurate rate in evaluating the epiphyaeal plate extension from osteosarcoma by X-ray and MRI was 44.44% and 100% respectively.The positive reactive rate of BMP-2 in tumor body,epiphyseal plate soak district,normal epiphyseal plate and normal tissue nearby the tumor was 88.89%(32/36),99.44%(34/36),10.00%(1/10) and 20.00%(2/10) respectively.Conclusion MRI is more sensitive to radiography in evaluating the epiphyseal plate involved by osteosarcoma,the higher positive reactive rate of BMP-2 protein is correlated to the epiphyseal plate extension of osteosarcoma.
