Selection of donors of living related liver transplantation for Wilson’s disease
- VernacularTitle:亲属活体供肝移植治疗肝豆状核变性时供者的选择
- Author:
Feng CHENG
;
Xuehao WANG
;
Feng ZHANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Living Donors;
Hepatolenticular degeneration
- From:
Chinese Journal of Organ Transplantation
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize experience of selection of donors of living related liver transplantation (LRLT) for Wilson’s Disease.Methods Twenty-nine cases of Wilson’s disease were subjected to LRLT in our center. A retrospective data analysis was carried on 70 potential donors. Results Twenty-three of the 70 potential donors were excluded. The causes were as follows: family and traditional background (n=10, 43.5 % ), copper metabolism abnormality, serum ceruloplasmin 100 ?g (n=6, 26.1 % ), hepatic steatosis (n=4, 17.4 % ) and hepatitis B (n=3, 13 %). The grafts were right liver (n=10) and left liver (n=19). Graft-recipient weight ratio was ( 1.38 ? 0.44 ) %. All donors recovered completely. Perioperative surgical complications occurred in 3 donors and were cured without reoperation, temporary biliary leakages (n=2) as well as postoperative bleeding from the wound of liver (n=1). Conclusions Major impact on living relative donors for Wilson’s Disease is traditional background, copper metabolism abnormalities, hepatitis B and hepatic steatosis. Comprehensive preoperative evaluation of potential donors and harvesting liver surgery innovation ensure the donor safety and graft quality.
