Study of association between HLA class Ⅱ haplotypes and pemphigus vulgaris in Han nation of northeast China
- VernacularTitle:中国北方汉族寻常型天疱疮与HLA-Ⅱ类基因单倍型的相关性研究
- Author:
Long GENG
;
Ning ZHAI
;
Xiuping HAN
;
Hongxi NIU
;
Fangji SONG
- Publication Type:Journal Article
- Keywords:
Pemphigus vulgaris;
HLA-DR,DQ;
Haplotype;
Chinese
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between pemphigus vulgaris(PV) and HLA-DR,DQ haplotypes in Han nations of northeast China.Methods:Polymerase chain reaction-sequence specific primers(PCR-SSP) method was used to detect the HLA-DRB1 and DQB1 alleles of 27 PV patients of Han nation of northeast China, analysed haplotyes and compared with 99 healthy controls.Results:Compared with control group, the frequencies of the haplotypes of HLA-DRB1*140x-DQB1*0503,DRB1*140x-DQB1*0201,DRB1*120x-DQB1*0503 and DRB1*140x-DQB1*0302 increased significantly in PV group. After statistical test, the difference between the two groups was significant.Conclusion:The special haplotypes may contribute to genetic susceptibility to PV in northeast Chinese.
