Effect of simvastatin on the osteoclastic resorption stimulated by PTHrP and anabolism with murine calvarial organ culture in vitro
- VernacularTitle:辛伐他汀对PTHrP诱导的破骨细胞性骨吸收及小鼠颅盖骨代谢的影响
- Author:
Luyu HUANG
;
Yunyu HU
;
Huiren TAO
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Osteoclast;
Bone resorption;
PTHrP
- From:
Orthopedic Journal of China
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study the effect of simvastatin in the osteoclastic resorption stimulated by PTHrP and murine bone anabolism in vitro.[Method]The bone resorption activities of the osteoclast stimulated by PTHrP were evaluated after treatment with simvastatin for 8 days in vitro;the concentration of Ca~(2+) in the supernatant was also detected by atomic absorption spectrometer.The concentration of ALP and Ca~(2+) of the supematant in murine calvarial organ culture were detected.The histology of calvaria was observed.[Result]Simvastatin greatly inhibited the osteoclastic bone resorption stimulated by PTHrP in vitro and reduced the release of Ca~(2+).Simvastatin increased the ALP activities and bone mineralization of murines calvarial organ culture in vitro.[Conclusion]Simvastatin may inhibit the osteoclasric resorption stimulated by PTHrP and promote osteoblast differentiation and bone mineralization in vitro,thus play an important role in the prevention and treatment of osteoporosis.
