Relationship between P-glycoprotein,Survivin expression and chemotherapy outcome in osteosarcomas
- VernacularTitle:骨肉瘤中P-糖蛋白、Survivin的表达与化疗疗效的关系
- Author:
Min DAI
;
Tao NIE
;
Xizhen WAN
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
P-glycoprotein;
Survivin;
Immunohistochemistry
- From:
Orthopedic Journal of China
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the relationship between Pglycoprotein,survivin expression and chemotherapy outcome.[Method]The expressions of P-glycoprotein,and of survivin were examined by the immunohistochemistry in 38 specimens of preoperation biopsy of osteosarecomas.[Result]The response rate of the P-glycoprotein positive group was lower than that of P-glycoprotein negative group.The response rate of the survivin overexpression group was significant lower than survivin was found to be more valuable in predicting chemotherapy results.[Conclusion]The expressions of P-glycoprotein,and of survivin are clearly associated with osteosarcomas response to chemotherapy in osteosarecoma and survivin is a more valuable parameter.
