Protective effects of divitamins notonginseng and cinnarizine capsule against acute cerebral ischemia
- VernacularTitle:二维三七桂利嗪胶囊对急性脑缺血的保护作用
- Author:
Xianghua XIAO
;
Xiuling DENG
;
Yan WANG
;
Juntian LIU
;
Zhuyun WANG
- Publication Type:Journal Article
- Keywords:
divitamins notonginseng and cinnarizine capsule;
acute cerebral ischemia;
neuroprotective effect
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of divitamins notonginseng and cinnarizine capsule(DNCC) on acute cerebral ischemia.Methods ICR mice were administered three doses of DNCC(420,210,and 105mg/kg;ig.) for ten days,then the gasping time after decapitation was recorded.After three doses of DNCC(292,146,and 73mg/kg;ig.) were given respectively for ten days in rats,the effects of DNCC on the infarct size,histological changes and neurological function scores caused by focal cerebral ischemia which was induced by middle cerebral artery occlusion were investigated.Results DNCC prolonged the gasping time of mice after decapitation and improved the neurological function scores,cerebral ischemia injury and decreased the infarct size in rats.Conclusion DNCC has a protective effect against acute cerebral ischemia.
