Protective effect of fructose-1,6-diphosphate on myocardium during coronary artery bypass graft
- VernacularTitle:1,6-二磷酸果糖在冠脉搭桥术中对心肌的保护作用
- Author:
Wei WANG
;
Guixia JING
;
Qiugui LIU
- Publication Type:Journal Article
- Keywords:
fructose-1,6-diphosphate;
cTnI;
CK-MB;
oxygen free radical;
CABG
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cardio-protective effects of fructose-1,6-diphosphate on myocardium during coronary artery bypass graft.Methods A total of 30 patients were treated with coronary artery bypass graft(CABG) and divided into group A(treated group) and group B(control group) randomly.Each group included 15 patients.In the treated group,patients were treated with FDP three days before CABG and treated with FDP before cardiopulmonary bypass(CPB).FDP was replaced by 0.154mol/L NaCl of the same volume in control group.Blood samples were collected from all patients after induction and at 1h,4h,24h and 48h after aortic declamping to measure the serum concentration of cTnI,CK-MB,SOD and MDA.Results The levels of CK-MB and cTnI at 1h,4h,24h and MDA at 1h,4h after reperfusion were significantly lower in the treated group than those in the control group(P
