Clinical study on Taxol-based combination chemotherapy for patients with advanced gastric cancer
- VernacularTitle:含紫杉醇方案治疗晚期胃癌的临床观察
- Author:
Yusheng WANG
;
Shanchuan WANG
;
Xiaoling LIU
;
Jun GAO
;
Zhaoling YANG
- Publication Type:Journal Article
- Keywords:
Taxol;
Combination chemotherapy;
Gastric cancer;
Paclitaxel;
Fluorouracil;
Cisplatin
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and toxicity of Taxol-based chemotherapy in patients with advanced gastric cancer. Methods Thirty-one patients with advanced gastric cancer were treated with two kinds of Taxol-based chemotherapy schedule. The treatment schedule were composed of paclitaxel and fluorouracil(TF) or cisplatin(TP). The patients who had had chemotherapy with fluorouracil were arranged to TP group,others to TF group. A treatment cycle lasted 21 days. The efficacy was evaluated after two cycles of the chemotherapy. Results total efficiency rate of two groups was 45.2 %; the efficiency rate of TF was 47.4 %; the rate of TP was 41.7 %; CBR was 80.6 %. The main side effect of toxicity were neutropenia and nausea as well as vomiting. Conclusion Taxol-based combination chemotherapy is a high response protocol with mild toxicity. TP schedule has a high efficiency for advanced gastric cancer.
