Clinical observation of FOLFOX4 protocol for advanced colorectal cancer
- VernacularTitle:FOLFOX4方案治疗晚期结直肠癌的临床观察
- Author:
Dongping WU
;
Jieqing LU
;
Feng TAO
;
Jianfang WANG
;
Songxiang WANG
- Publication Type:Journal Article
- Keywords:
FOLFOX4;
Oxaliplatin;
LV;
5-Fu bolus;
Colorectal cancer
- From:
Cancer Research and Clinic
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and toxicity of the protocol of FOLFOX4 for advanced colorectal cancer. Methods 27 patients received FOLFOX4oxaliplatin 85 mg/m2 as a 2-hour infusion on day 1 and a 2-hour infusion of LV (200 mg?m-2?d-1) followed by a 5-Fu bolus (400 mg?m-2?d-1) and 22-hour infusion (600 mg?m-2?d-1) for 2 consecutive days every 2 weeks. Four courses were carried out with an interval of one month. Results The total effective rate was 44.44 %, CR(3.70 %), PR(40.74 %). Median survival of all patients was 10.0 months. Mean Survival was 11.5 months. One year survival rate was 30.02 %. Median duration of 12 effective patients were 5.3 months. Median survival of effective patients and non-effective was 11.8 and 8.5 months respectively(P
