Improved left ventricular endocardial border echo resolution by perfluoropropane-albumin microsphere injection: a multiple center stage Ⅲ clinical study
- VernacularTitle:全氟丙烷人血白蛋白微球注射剂左心超声造影增强左心室内膜分辨的Ⅲ期多中心临床研究报告
- Author:
Xinfang WANG
;
Peili GONG
;
Mingxing XIE
;
Zhaohui WANG
;
Yale HE
;
Hongwen FEI
;
Yuan LIU
;
Liang CUI
;
Yafeng WU
;
Lin XU
;
Xianhong SHU
;
Cuizhen PAN
;
Shizhen LIU
;
Guang ZHI
;
Xiaoxia WU
;
Haiyan NIU
;
Yun ZHANG
;
Mei ZHANG
;
Guihua YAO
;
Yanbin SI
;
Xiaoyu XIA
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Contrast media;
Clinical trials, phase Ⅲ;
Perfluoropropane-albumin microsphere
- From:
Chinese Journal of Ultrasonography
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05 ). After once injection both observers considered the number of clearly recognized endocardial border segments increased significantly. The number evaluated by observers A increased from 2.68 ? 0.95 to 5.99 ? 0.10 while from 2.82 ? 1.03 to 5.99 ? 0.11 by observers B( P 0.05 ). The average contrast enhancement rate of LV endocardial border was 99.7 %. Perfluoropropane-albumin microsphere injection had no significant effection on vital signs such as blood prssure, heart rate and respiration. Electrocardiogram didn′t change markedly and the variance of the laboratory findings like blood and urine routine examination, hepatic and renal function was in normal range. Only one case( 0.33 %) had slight side-effects who suffered from mild nausea and diarrhea, which suggested the clinical safety of this contrast agent. Conclusions Perfluoropropane-albumin microsphere injection could enhance the resolution of LV endocardial borders and make the judgement of regional myocardial movement easier. It has little side-effects and will be appropriate for clinical use.
