Effects of iodine on the thyroid sodium iodide symporter mRNA expression and thyroid function in rats
- VernacularTitle:碘对大鼠甲状腺钠碘转运体mRNA表达及甲状腺功能的影响
- Author:
Xiuling NIE
;
Yuqin YAN
;
Zupei CHEN
- Publication Type:Journal Article
- Keywords:
Iodine;
Hypothyroidism;
Sodium iodide symporter;
Rat, Wistar
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of different iodide intakes on the thyroid sodium iodide symporter (NIS) mRNA expression, thyroid hormones, urinary iodine and tissue iodine in thyroid were observed. NIS mRNA expression was elevated; and urinary iodine, thyroid tissue iodine and thyroid hormones were significantly lowered in low iodine group. In high iodine group, NIS mRNA expression was inhibited and thyroid hormones decreased. The results show that NIS is the important component of this autoregulatory mechanism. Both low and high iodine intakes can lead to hypothyroidism.
